The migration of SREBP2 into the nucleus was impeded by HCMV infection, with the amounts of SREBP2 in the nucleus decreased by 56.66 ± 3.21% and 69.23 ± 4.01% at 3 and 7 days of differentiation, respectively, compared to uninfected cells. The gene discussed is SREBF2; the disease is cytomegalovirus infection.