However, the remaining 4 patients were found to have obstructive CAD on ICA; the lack of evidence of RWMA or myocardial edema or infarction in these 4 patients suggest that their presentation may have been due to mild myocardial ischemia leading to mild elevation of high-sensitivity cTnI levels, which may not be within the sensitivity of multiparametric CMR. This evidence concerns the gene TNNI3 and edema.