Last but not the least, three hypomethylated genes in MTF_43 (B‐ALL twin)—PLEK2, MRAS, and RXRA—display a correlation with mRNA hyperexpression (Figure S4) and mRNA hyperexpression, and they are associated with poor outcomes in pediatric B‐ALL cohort (Figure 5E–G). The gene discussed is PLEK2; the disease is acute lymphoblastic leukemia.