NLRP3 and major depressive disorder: Moreover, MCC950, an inhibitor of the NLRP3 inflammasome, has been shown to ameliorate depression‐like behavior in mice by suppressing the activation of NLRP3 inflammasome in the hippocampus and reducing the expression levels of NLRP3, ASC, and IL‐1β (Zhai et al., 2018).