Alterations of CDK6, CDKN2A, CDKN2B, FGFR2, and MYC were more likely to be detected in WHO grade 4 astrocytoma, while variations of chromosome 19q had a higher frequency in WHO grade 2–3 astrocytoma. The gene discussed is FGFR2; the disease is astrocytoma (excluding glioblastoma).