INS and type 2 diabetes mellitus: Mutations in the HNF4α gene have been linked to the risk of T2D and maturity‐onset diabetes of the young (MODY).[26] In addition, in HFD mice, ablation of hepatic HNF4α results in insulin resistance.[27] In our experiments, we found HNF4α knockdown impaired AKT phosphorylation regardless of statin treatment (Figure 6G).