AKT1 and cancer: It's worth noting that the hyper‐activating PI3K/AKT pathway is associated with aggressive hepatocellular carcinoma,[33] and atorvastatin has been reported to decrease proliferation and invasiveness of hepatocytes by AKT signal.[34] In our investigation, we found statins downregulated hepatic insulin signaling, further indicating that statins potential to prevent cancer may involve inhibiting AKT phosphorylation.