It's worth noting that the hyper‐activating PI3K/AKT pathway is associated with aggressive hepatocellular carcinoma,[33] and atorvastatin has been reported to decrease proliferation and invasiveness of hepatocytes by AKT signal.[34] In our investigation, we found statins downregulated hepatic insulin signaling, further indicating that statins potential to prevent cancer may involve inhibiting AKT phosphorylation. This evidence concerns the gene AKT1 and hepatocellular carcinoma.