AKT1 and Insulin resistance: Some researchers indicated that statins activated hepatic gluconeogenesis, which finally leads to dysglycemia.[12] Blockage of the mevalonate pathway decreased prenylation might also involve inflammation or AKT phosphorylation to cause insulin resistance.[13, 14] However, it is still unclear how statin therapy‐related increases in insulin resistance work, either the key organ of the statin‐induced insulin resistance or the detailed molecular mechanism.