PAQR9 and metabolic syndrome: Paqr9 is primarily expressed in hepatocytes (Figure S2, Supporting Information); however, we have recently revealed that this gene also functions in the pancreas to control glucose homeostasis.[35] More interestingly, PAQR9 altered dyslipidemia in addition to insulin sensitivity without statin treatment (Figure 3), indicating that PAQR9 has complicated metabolic activity.