NSUN6 and neoplasm: In addition, IHC results showed that RDA51 (an HR repair biomarker) expression decreased in tumor tissues of the NSUN6 knockdown group compared with the control group but increased in the NDRG1 rescued group (Fig. 6D), which agreed with the results illustrated in Fig. 5E. Moreover, we observed an increase in NSUN6 expression in SiHa-CDXs following irradiation compared to those that did not receive irradiation (Fig. 6D).