Importantly, the breakpoint distribution within the ABL1 gene differed significantly between CML and ALL patients (p = 3.38e-05; see Fig. 1D), with a higher accumulation of breakpoints in the 5’ part of the ABL1 breakpoint area in CML and in the 3’ part of the area in ALL. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.