The specific mechanism is that NEAT1 can up-regulate the expression of SP1 and down-regulate the expression of apoptosis-related proteins c-PARP and c-caspase3 through sponge miR-29b-3p, thereby inhibiting the apoptosis of MM cells and enhancing the tolerance of MM cells to bortezomib [70]. Here, NEAT1 is linked to Miyoshi myopathy.