Knockdown of NEAT1 can target down-regulate the expression of miR-34a and up-regulate the expression of HMGB1, thereby inhibiting the expression of autophagy related proteins Bclin-1 and ULK1 and the ratio of LC3II/I, and enhancing the sensitivity of CRC cells to 5-Fu [64]. This evidence concerns the gene NEAT1 and colorectal carcinoma.