In BC paclitaxel-resistant SKBR-3/PR cells, knockdown of NEAT1 can up-regulate the expression of miR-133b and down-regulate the expression of downstream CXCL12 protein, which promotes cell cycle arrest in G0/G1 phase and promotes the sensitivity of SKBR-3/PR cells to paclitaxel [56]. The gene discussed is NEAT1; the disease is breast cancer.