NEAT1 is able to act as a scaffold to affect chromatin remodeling in cancer cells, increase the expression of H3K27ac and lead to increased levels of acetylation in the ALDH1 and c-Myc promoter regions, which in turn upregulates the expression of the cancer stemness factors SOX2, Nanog, and OCT4, and enhances the stemness of colorectal cancer cells and increases their resistance to 5-Fu [65]. The gene discussed is POU5F1; the disease is cancer.