The pathway enrichment analysis indicated that several pathways were significantly enriched, including interferon signaling (Fig S3A), inhibition of angiogenesis by Thrombospondin-1 (TSP1) (Fig S3B), protein ubiquitination pathway (Fig S3C), role of tissue factor in cancer (Fig S4A and S4B), NOD1/2 signaling pathway (Fig S5), protein kinase A signaling (PKA) (Fig S6), IL-13 signaling pathway and WNT/β-catenin signaling. The gene discussed is F3; the disease is cancer.