CD4 and neoplasm: In a mouse tumor model, HN-1 significantly inhibited 4T1 tumor growth and increased the infiltration of anti-tumor immune cells (DCs and CD4+ and CD8+ T lymphocytes), while the proportion of suppressive immune cells (regulatory T (Treg) cells and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs)) was significantly reduced.