MELK and neoplasm: The results of the FCM assay indicated that compared with MELK knockdown or RT treatment alone, the combination of MELK knockdown with RT treatment led to the lowest infiltration of TAMs, and antitumoral M1 polarization was stimulated while M2 polarization was substantially restrained; the combined treatment induced much more CD8+ T-cell recruitment to tumor tissues (Fig. 8J-Q).