Consistently, our data revealed a significant positive correlation between the infiltration of TAMs and CCL2 expression in HCC,, and what is also with noticing is that a negative correlation was revealed between CCL2 and immune cells including B cells, NK cells and T cells especially CD8 + T cells, which implies the role of CCL2 in tumor immune microenvironment and that inhibition of CCL2 may contribute to strengthening the antitumor immune response. The gene discussed is CCL2; the disease is hepatocellular carcinoma.