Additionally, Hyperandrogenism, a hallmark of PCOS, is linked to the promotion of fibrogenic gene transcription and regulation of epithelial-mesenchymal transition (EMT) via the TGF-β signaling pathway, as evidenced in studies using the androgen analog dehydroepiandrosterone in PCOS rat models to induce ovarian fibrosis [96]. The gene discussed is TGFB1; the disease is polycystic ovary syndrome.