FBN2 and congestive heart failure: The E/A ratio was a useful parameter in detecting congestive heart failure in cats with HCM, and several Doppler echocardiography variables have been assessed to evaluate the left ventricular filling pressure such as the ratio of transmitral flow velocity between peak E and peak (E/A), and the ratio of E velocity to the relaxation time (IVRT).The upregulation of integrin subunit alpha M (ITGAM), elongin B (ELOB), and fibrillin 2 (FBN2) was observed in this study.