Particularly, the identification in FAP patients of a specific microbiota composition with some taxa found both in mucosal and faecal specimens and associated with the specific derangement of Wnt/β-catenin and PI3K/mTOR signallings may help in developing assays to differentiate patients with early-stage adenomas often missed by FIT screening. Here, PIK3CG is linked to Familial adenomatous polyposis.