We also recently showed that protracted COX-2 activity in the wound stroma following needle biopsy of breast tumors accelerates pro-metastatic changes via substantial accumulation of infiltrating M2-like Mφ and their paracrine factors, effects that were mitigated by oral administration of celecoxib in a syngeneic mouse model of breast cancer [13]. The gene discussed is PTGS2; the disease is breast cancer.