Analysis of Py230 tumors injected with Cx-NP/PLA-gel revealed a 1.4-fold increase in E-cadherin+/CK+ cancer cells compared to Ctrl-NP/PLA-gel (56.6 vs. 41.6, 95% CI 51.8–68.4 vs. 33.9–45.4; p = 0.029) and 1.9-fold decrease in vimentin+/CK+ cells in Cx-NP/PLA-gel injected tumors, compared to biopsied tumors injected with Ctrl-NP/PLA-gel (6.2 vs. 11.9, 95% CI 2.5–8.8 vs. 9.4–14.4; p = 0.029; Fig. 5d, Supplementary Fig. 8), suggesting a significant reduction in the level of cancer cell EMT. This evidence concerns the gene CDH1 and cancer.