Of the top 10 drugs, Buspirone (5-Hydroxytryptamine 1 A receptor antagonist)(Osei-Owusu and Scrogin 2004) and Oxybuprocaine (anaesthetic) (Hung et al. 2010) have experimental evidence for an effect on RHR but are not current drug targets for cardiovascular diseases. This evidence concerns the gene ADRB1 and cardiovascular disorder.