Main mast cells mediators have been described in the tumor microenvironment, including chymase, tryptase, VEGF, Histamine, TNF-α, MMP2, MMP-9, TIMPs, NGF, and sphingosine-1-phosphate (Donato et al. 2014; Komi et al. 2020). This evidence concerns the gene MMP2 and neoplasm.