Furthermore, lopinavir has been shown to induce strong ER stress not via proteasome inhibition, but rather via reactive oxygen species-dependent Mitogen-Activated Protein Kinase 8 (JNK) activation [42] and has been previously described to induce ER stress in breast cancer cells, either triple-negative or non-triple-negative [43, 44]. The gene discussed is MAP3K8; the disease is breast carcinoma.