At the same time, the ability to degrade misfolded proteins is significantly enhanced during malignant transformation and as a consequence of increased breast cancer aggressiveness via the Nuclear Respiratory Factor 1(NRF1) and Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) transcription programs, to avoid detrimental effects of misfolded proteins [2]. This evidence concerns the gene NRF1 and breast carcinoma.