In line with this notion, mutations in PCa that activate PI3K (such as prostate-specific Pten loss) prime or promote obesity-driven PCa aggressiveness in conjunction with other signalling pathways, such as loss of Ptpn1 [221], IL6/pSTAT3 signalling activation [222] or Pml co-deletion [223]. Here, PTPN1 is linked to posterior cortical atrophy.