IGF1 and uveal melanoma: To further investigate the association of SGE-depleted alleles with increased IGF-1 levels, we obtained The Cancer Genome Atlas (TCGA) RNA-seq data28 for uveal melanomas and found a strong association of loss-of-function BAP1 alleles with IGF1 mRNA expression (P < 0.001, two-sided Mann−Whitney−Wilcoxon test) and poor prognosis by Kaplan−Meier estimate (P = 0.004) (Fig. 5c,d).