BAP1 and neoplasm: Finally, to further explore the use of SGE data and identify novel BAP1 variants, we queried tumor sequence data for a cohort of 394,756 patient samples in the Foundation Medicine database29 and found 12,172 (3.1%) unique BAP1-altered specimens harboring 13,283 BAP1 alterations, including all possible changes at codon R146 (Extended Data Fig. 9a−d).