For instance, the loss of UBQLN1 is associated with enhanced cell migration and induction of EMT (Shah et al. 2015), silencing UBQLN2 activates P38MAPK, enhancing the radiosensitivity of esophageal squamous cell carcinoma(Wang et al. 2023). The gene discussed is UBQLN2; the disease is esophageal squamous cell carcinoma.