For instance, UBQLN4 over-expression promotes metastasis and poorly differentiated outcomes in cervical cancer, leading to adverse prognosis(Wang et al. 2022); additionally, UBQLN4 activates the Wnt-β-catenin pathway, facilitating the progression of hepatocellular carcinoma (HCC)(Yu et al. 2020); activated by C/Ebpβ, UBQLN4 promotes proliferation, migration, and invasion in colorectal cancer through the Wnt/β-catenin signaling pathway (Tang et al. 2021). The gene discussed is UBQLN4; the disease is colorectal cancer.