There have been many studies have found that MYC(Wei et al. 2019),mTOR(Wang et al. 2018; Xu et al. 2024),SOX2(Yang et al. 2023),Bcl-2(Chen et al. 2022)and so on, as downstream signaling molecules of PI3K/AKT, promote the proliferation and metastasis of NSCLC. Here, SOX2 is linked to non-small cell lung carcinoma.