DTL, DUSP1, NFKBIA and SOCS2 genes closely related to the degree of pathogenicity of hepatocellular carcinoma and giving a good valuable insights about the progress of HCC and prognosis and this in turn prove our suggestion in the role of sorafenib targeting hepatocellular carcinoma by loading on the ecofriendly synthetic nanocomposite and by the comparison was made between the group treated with ZnO-SPION-Ag nanocomposite and the positive control group, it was approved that it has excellent anticancer effect on hepatocellular carcinoma effect. This evidence concerns the gene DTL and hepatocellular carcinoma.