In conclusion, DTL, DUSP1, NFKBIA, and SOCS2 were found to be closely related to HCC and may give significant information for improving HCC treatment and prognosis. Our results showed that the anticancer effect of the nanocomposite loaded with sorafenib better than sorafenib drug or nanocomposite separated. This evidence concerns the gene DUSP1 and hepatocellular carcinoma.