The major signaling pathways (KEGG) related to these genes included the PI3K-Akt signaling pathway (hsa04151, 73 genes), pathways in cancer (hsa05200, 66 genes), JAK-STAT signaling pathway (hsa04630, 62 genes), cell cycle (hsa04110, 59 genes), cytokine-cytokine receptor interaction (hsa04060, 59 genes), MAPK signaling pathway (hsa04010, 44 genes), Ras signaling pathway (hsa04014, 41 genes), Rap1 signaling pathway (hsa04015, 36 genes), and calcium signaling pathway (hsa04020, 27 genes). Here, AKT1 is linked to cancer.