Additionally, when comparing 4T1 IRF5-low BC EVs to EVs derived from an unrelated non-metastatic BC cell line 67NR, they detected increased exosome secretion, lung organotropism, and equivalent uptake by immune cells44, which is nearly identical to our findings in 4T1 IRF5-low and 4T1-IRF5 high expressing cells. This evidence concerns the gene IRF5 and breast cancer.