Among the altered genes related to the cell cycle, MYC, Cyclin A2 (CCNA2), Cyclin E2 (CCNE2), Cyclin D2 (CCND2), CD133 (PROM1) and Cyclin-dependent kinase (CDK1) were more highly expressed in the HSCs from AML condition than in those of the Healthy condition (Fig. 4). Here, PROM1 is linked to acute myeloid leukemia.