To identify ILC2-specific SEs, we performed H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) of lung ILC2s, defined as Lin−CD45+Thy1+ST2+ cells, and lung CD4 T cells in house dust mite-induced asthma models, which recapitulate activated ILC2s and activated Th2 cells in vivo, respectively (Supplementary Fig. 1a, b). This evidence concerns the gene IL1RL1 and asthma.