The transcriptional complexes of Twist1, YY1, and p300 promote the malignancy of HCC by forming phase separation condensates at the super-enhancers of miR-9 to activate its expression, and metformin can disrupt these phase separation condensates to decrease miR-9 expression and the malignancy of HCC [33]. The gene discussed is EP300; the disease is hepatocellular carcinoma.