SLC12A3 and hepatocellular carcinoma: Similarly, the outcompeting of lenvatinib-resistant cells (Huh7R/PLC-PRF-5R) against lenvatinib-sensitive cells (Huh7m/PLC-PRF-5m) was observed in xenograft tumors from CC group but not NCC group, which further indicated the potential existence of cell competition between lenvatinib-resistant HCC cells and sensitive HCC cells (Fig. 1C; Supplemental Fig. S1O).