Of note, it has been reported that AMPK modulates energy and metabolic homeostasis through phosphorylating key glycolytic enzyme PFKFB3 and, on the other hand, AMPK-induced recycle signal can be effectively activated to devour cell debris and then promote the growth of lung cancer [65]; therefore, the detailed functions of AMPK-ENO2 axis and the effects of AMPK on lenvatinib-sensitive HCC cells will be clarified in the future. This evidence concerns the gene HK1 and hepatocellular carcinoma.