For example, an intronic variant in ALMS1 (NM_015120.4:c.450+11 T > C) with conflicting ClinVar interpretations, has a high rhesus macaque AF of 0.23 and homozygote frequency (HF) of 0.06 (66 of 1179), suggesting that it is likely benign. The gene discussed is ALMS1; the disease is hydrops fetalis.