For example, a missense variant in FOXP1 (NM_032682:c.G64A:p.G22S), with a human AF of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$4.0\times {10}^{-6}$$\end{document}4.0×10−6 and ClinVar “Uncertain_significance”, has a macaque AF of 0.37 and HF of 0.14 (256 of 1837), suggesting it is likely benign. This evidence concerns the gene FOXP1 and atrial fibrillation.