Similarly, a missense variant in ABCC6 (NM_001171:c.T2237C:p.I746T), predicted deleterious by Polyphen and SIFT and classified as “Uncertain_significance” by Clinvar, has a high macaque AF of 0.38 and HF of 0.15 (280 of 1843), indicating it is likely benign. This evidence concerns the gene ABCC6 and hydrops fetalis.