CXCL2 and cancer: Cluster 6 upregulates CCL20, which promotes cancer cell migration and therefore progression / metastasis58,59; CXCL3, which also promotes metastasis in pancreatic cancer60; the pro-inflammatory cytokine IL1B, as well as other chemokines CXCL2 and CXCL8 (Fig. 2c, d).