Cluster 5 TAMs are characterized by their upregulation of stress-inducible heat shock transcripts (Fig. 2c, e), which are associated with a broad number of features of cancer development75, including HSPA6, HSPA1B, HSPA1A, DNAJB1, HSPB1, HSPH1, HSPD1, HSP90AA1 and BAG3, which interacts with heat shock proteins and is also induced under stressful stimuli76. This evidence concerns the gene HSPB1 and cancer.