Furthermore, we associated particular macrophage subsets with cancers of varying phenotype, finding that melanoma brain metastases, and not glioblastomas, harboured a large proportion of 12_MBMMac macrophages, which uniquely upregulated LRMDA, a melanocyte differentiation factor, indicative of an interaction between tumour cells and TAMs in this context. Here, LRMDA is linked to neoplasm.