Cluster 5 TAMs are characterized by their upregulation of stress-inducible heat shock transcripts (Fig. 2c, e), which are associated with a broad number of features of cancer development75, including HSPA6, HSPA1B, HSPA1A, DNAJB1, HSPB1, HSPH1, HSPD1, HSP90AA1 and BAG3, which interacts with heat shock proteins and is also induced under stressful stimuli76. The gene discussed is HSP90AA1; the disease is cancer.