However, most of the data were obtained in experimental animal models of psychosis in which mGlu2/3 receptor agonists or mGlu2-positive allosteric modulators have consistently produced beneficial effects (Schoepp and Marek, 2002; Swanson and Schoepp, 2003; Hackler et al., 2010; Horiguchi et al., 2011; Griebel et al., 2016; Wischhof and Koch, 2016; Hideshima et al., 2018). The gene discussed is GRM2; the disease is psychotic disorder.