Using the novel object recognition test for the study of recognition memory, we found that cognitive impairment caused by methamphetamine in mice was corrected by genetic deletion or selective pharmacological blockade of either Group 2 metabotropic glutamate (mGlu2) or mGlu3 receptors, two mGlu receptor subtypes that control synaptic activity by restraining glutamate release. This evidence concerns the gene GRM2 and Cognitive impairment.