This resulted in skin flushing and angioedema.[7] There are also reports of the relationship between house dust mites and MRGPRX2, a molecule involved in IgE-independent neuroimmunomodulation of itch and allergy response[13] and Kumar et al[14] have reported potential therapeutic inhibitory molecules to tackle the activation of MRGPRX2. This evidence concerns the gene IGHE and angioedema.