Recent studies have found a positive correlation between amyloid deposition of transthyretin (TTR) and the thickness of the LF and epidural fat.[105,106] Maurer et al[107] detected amyloid deposits in the LF of >1/3 of patients with LSS, and in more than half of these patients the precursor of the deposited amyloid was TTR. This evidence concerns the gene TTR and amyloidosis.