Leptin is also closely associated with IL-6, and leptin can upregulate the expression of IL-6 through the activation of the NF-κB signaling pathway leading to LF inflammation.[55,56] It is worth noting that leptin was originally a hormone secreted by adipose tissue, and leptin levels in human serum rise with increasing body fat,[57] suggesting that obesity is one of the factors in LFH, which shows that the inhibition of leptin expression and weight loss are important for alleviating LF inflammation. The gene discussed is LEP; the disease is obesity disorder.