The tumor immune microenvironment is crucial in shaping disease progression and therapeutic responses in cancer.[51] It has been shown that lncRNAs modulate tumor progression by influencing the TME.[52] Immune infiltration analyses reveal a greater presence of M2 macrophages in the high-risk group, which are known for their immunosuppressive roles by secreting cytokines like IL-10 and TGF-β,[53,54] potentially inhibiting T cell activation and proliferation. This evidence concerns the gene TGFB1 and cancer.