SLC7A11 and cancer: Disulfidptosis is a recently discovered form of programmed cell death that distinguishes itself from traditional mechanisms such as apoptosis,[15] autophagy,[16] and necroptosis.[17] This process is initiated by a deficiency in NADPH during cancer cell starvation, which disrupts cysteine metabolism through SLC7A11, leading to the accumulation of abnormal disulfide bonds.