The study by Tada et al pointed out that in the general population, the development and progression of ASCVD in patients with familial hypercholesterolemia are associated with serum RC levels.[33] In addition, several recent Mendelian randomization studies of other variants in genes encoding apolipoprotein C-III, LPL, and angiopoietin-like proteins 3, 4, and 8 have also shown an increased risk of ASCVD with elevated RC levels.[34–36]. This evidence concerns the gene LPL and atherosclerosis.