Finally, RC is involved in the process of atherosclerosis by accelerating the assembly of thromboplastin complex, up-regulating the plasminogen activator inhibitor-1 gene, and expressing plasminogen activator inhibitor-1 antigen to enhance platelet activity and promote its aggregation, leading to the formation of thrombus or microthrombus.[44–47]. Here, SERPINE1 is linked to atherosclerosis.