Regarding immune function recovery, CD4 + T lymphocyte counts < 200 cells/mm3 and lower CD4/CD8 levels are strongly associated with the development of opportunistic infections and an increased risk of death in patients with HIV.[12,13] In our study, the CD4 + cell count at 48 weeks increased compared with the baseline, and the CD4/CD8 ratio increased by 0.29-fold. Here, CD8A is linked to Opportunistic infection.