IgD+CD38br AC, IgD+CD38dim AC, TDDN (CD4-CD8-) AC, CD3 on NKT, HLADR on CD14+ monocytes, HVEM on EM CD4+, and CD39+ T regulatory cells (Tregs) were potential risk factors for prostate cancer (P < .05), as shown in Table 2. Here, CD4 is linked to Familial prostate cancer.