In mice with melanoma, a high-fat diet can lead to dysbiosis of the gut microbiota, manifested by an increase in Clostridium, which can induce tumor infiltration of melanoma by activating nuclear factor kappa-B signaling in macrophages.[4] In sarcoma, TLR5 recognizes the gut microbiota and promotes myeloid-derived suppressor cell mobilization, thereby accelerating tumor growth. Here, TLR5 is linked to melanoma.