However, the increased synovitis was not consistently associated with a change in osteoclast number for the cuboid or talus vs tibiale, which may represent a ceiling of erosive activity for the cuboid at 5-months (Fig 4L–4P; TNF-Tg cuboid 0.041±0.020 vs tibiale 0.027±0.025 TRAP/tissue area, p>0. This evidence concerns the gene TNF and synovitis.