Yang Sixia established a mouse model of Alzheimer’s disease and HT22 neuronal cell iron death in vitro and found that SAL treatment improved cell survival, reduce lipid peroxidation and ROS levels, and improved mitochondrial ultrastructure; the mechanism may be related to the Nrf2/HO-1 signaling pathway [29]. The gene discussed is HMOX1; the disease is early-onset autosomal dominant Alzheimer disease.