The risk of developing tuberculosis among HIV-positive children on ART was 2.22 times (AHR = 2.22; 95%CI: 1.65–2.79) whose CD4 count below the threshold (<200 cells/mm3) than children who had greater (≥200 cells/mm3) (I2 = 51.21%, p<0.001) and with no publication bias (p = 0.5623). This evidence concerns the gene CD4 and tuberculosis.