Sensitivity analyses using the risk models restricted to pneumonia in the inpatient setting did not substantively change model performance (C-statistic of the model including only clinical variables was 0.67; C-statistic of the model including only serum protein immunoassays was 0.64; C-statistic of the model including clinical variables and serum protein immunoassays was 0.69; C-statistic of the exploratory model including clinical covariates and C-reactive protein was 0.68 (S7 Table in S1 File). The gene discussed is CRP; the disease is pneumonia.