As the immune marker evaluation of Ing4-deleted mouse tumors showed increased TAMs (Gr-1loCD11b+F4/80+) and decreased GzmB+CD4+ T cells, we sought to determine the clinical significance of these findings by analyzing the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) gene expression data set [41,42]. The gene discussed is ING4; the disease is breast cancer.