Because NEPC typically arises as a consequence of lineage transformation from PRAD, we next looked at DLL3 expression in our adenocarcinoma cohort and found clear evidence of DLL3 expression within subsets of cells within CRPC–adenocarcinoma tumors (Fig. 4G and SI Appendix, Fig. S10G). The gene discussed is DLL3; the disease is prostate adenocarcinoma.