KLF8 and neoplasm: Two GRNs, albeit comprising a smaller number of tumor cells, showed high activity for the TCF7L2 regulon (along with KLF8, FOXK1, FOXP2, and BACH1) (labeled TCF7L2+) and CTCF (along with MAFG and NR1H) (labeled CTCF+), respectively (Fig. 2D and Dataset S6).