Specifically, YAP1 was high in PRAD/HGC but not NEPC (Fig. 1C, P < 1 × 10−4), while ASCL1 and other neuroendocrine-associated TFs were high in NEPC histologies but not PRAD/HGC (Fig. 1D and SI Appendix, Fig. S1C). This evidence concerns the gene ASCL1 and prostate adenocarcinoma.