TF and prostate adenocarcinoma: To study tumor cell heterogeneity specifically in CRPC PRAD and NEPC samples and reasoning that lineage plasticity is likely driven by transcription factor (TF) networks, we focused on shared and unique gene-regulatory networks (GRNs) across samples using single-cell regulatory network inference (SCENIC) (Fig. 2D, SI Appendix, Fig. S4 A–C and Dataset S5).