IRF2 and neoplasm: By implementing SCENIC, we found nine tumor-associated GRNs within the PtR and PtRP GEMMs including one defined by Stat1/2 and Irf2/7/9, validating our recent findings on the critical role of JAK/STAT signaling in initiating plasticity (Fig. 3 A and B and SI Appendix, Fig. S7 and Datasets S8 and S9).