KMT2A and cancer: For mutations observed in cancer (Figure S9A), predictions were biased toward being functional (COSMIC: 101 functional vs. 52 WT-like, OR = 2.92, p = 1.9e–8; MLL: 109 functional vs. 36 WT-like, OR = 4.99, p = 1e–15); whereas gnomAD database mutations were biased toward WT-like (27 functional vs. 50 WT-like, OR = 0.59, p = 0.051; Figure S9B).