CXCL8 and neoplasm: Previous studies implicate neurotrophic signaling as a promoter of malignant cell growth and survival across a variety of tumor types.100 Hypomorphic variants displayed lower expression of FGFR1, perhaps indicating a different pattern of reliance on growth factors with links to neuronal plasticity.101 Certain immune functions were also altered; IL-10 signaling molecules CXCL2 and CXCL8, implicated in neutrophil recruitment,102 were higher in the hypomorphic case, whereas NFATC1, a mediator of T cell activity, was downregulated.