Downregulation of FoxO1 levels or activity in the livers of diabetic mouse models results in lower plasma glucose concentrations and decreased hepatic glucose production (Altomonte et al. 2003, Samuel et al. 2006) Moreover, while deletion of the insulin receptor in the liver causes hyperglycemia, deletion of FoxO1 in the liver together with the insulin receptor normalizes serum glucose levels, indicating a critical role for hepatic FoxO1 in glucose metabolism. This evidence concerns the gene INSR and Hyperglycemia.