While de novo lipogenesis contributes to fatty liver and associated hepatic insulin resistance, lipid synthesis from FFAs is responsible for 60% of the TAG stored in the liver (Donnelly et al. 2005, Smith et al. 2020) Moreover, increased lipogenesis observed in patients with fatty liver is driven by the lipogenic substrate availability rather than paradoxical activation by insulin (Ter Horst et al. 2021). This evidence concerns the gene INS and Insulin resistance.