ADIPOQ and Insulin resistance: Dysfunctional adipose tissue releases pro-inflammatory factors such as TNF-α, IL-6, and IL-1β, and decreases the release of anti-inflammatory factors such as adiponectin and IL-10, exacerbating hepatic inflammation, insulin resistance, and steatosis (Abenavoli & Peta 2014, Stojsavljević et al. 2014).