ADIPOQ and hyperinsulinemic hypoglycemia, familial, 4: Studies have also demonstrated that adiponectin deficiency is associated with insulin resistance and is predictive of hepatic fibrosis in patients with MASLD (Savvidou et al. 2009, Nazal et al. 2010) that replenishing physiologic doses of adiponectin can reverse insulin resistance (Yamauchi et al. 2001, Savvidou et al. 2009, Li et al. 2020).