A recent 9-year follow-up population-based historical cohort study32 conducted in Israel reported a decrease (although not statistically significant) in incidence of pancreatic cancer (HR, 0.50; 95% CI, 0.15-1.71) in patients with T2D treated with GLP-1RAs compared with insulin.32 Our US population-based study, with 15 years of follow-up and a larger sample size, now extends these observations, suggesting that treatment of patients with T2D with GLP-1RAs vs insulin is associated with a significantly decreased incidence of pancreatic cancer (HR, 0.41; 95% CI, 0.33-0.50). The gene discussed is INS; the disease is type 2 diabetes mellitus.