SREBF1 and cancer: Studies have also shown that lncRNA KB-1460A1.5 acts as a tumor-suppressive lncRNA by inhibiting the mTOR signaling pathway, reducing the expression of downstream sterol regulatory element-binding protein 1 (SREBP-1), thereby attenuating the desaturation of polyunsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1), inducing cancer cell oxidative stress and iron death, exerting anti-tumor effects, and having therapeutic potential [112].