Through real-time fluorescence quantitative PCR (qRT-PCR) detection of TMZ-resistant and TMZ-sensitive GBM cell lines, it was found that the pseudogene of lncRNA protein disulfide isomerase family A member 3 (PDIA3P1) was highly expressed in TMZ-resistant GBM cell lines, and it was confirmed that the overexpression of PDIA3P1 destabilized the C/EBPβ-MDM2 complex by blocking ubiquitination mediated by MDM2 and stabilized the C/EBPβ protein, thereby reducing the sensitivity of GBM cells to TMZ [90]. This evidence concerns the gene MDM2 and glioblastoma.