PKM and glioma: For example, Liu et al. [73] demonstrated through functional experiments that LinC00689 promotes the expression of pyruvate kinase M2 (PKM2) by directly interacting with miR-338-3p, acting as a competitive endogenous RNA (ceRNA) to enhance glioma cell proliferation, migration, invasion, and glycolysis, which may offer new therapeutic targets and approaches for glioma treatment.