SPI1 and glioblastoma: Through research, it was found that LncRNA ZBED3 antisense RNA 1 (ZBED3-AS1) was downregulated in TMZ-resistant GBM tissues and cell lines (U251/TMZ and U87/TMZ), and it was experimentally verified that ZBED3-AS1 could bind to the Spi-1 proto-oncogene (SPI1) to block the transcriptional activation of platelet regulator protein (THBD) mediated by SPI1, thereby decreasing the TMZ resistance of TMZ-resistant cells [76].