However, the overexpressed lncRNAH19 and HOXD-AS2 competitively bound with KSRP (K-homology splicing regulatory protein) to enhance the expression of MGBT (methylguanine DNA methyltransferase) and prevent KSRP from binding to primary miR-198, thereby reducing the expression of miR-198 and promoting glioma resistance to temozolomide. The gene discussed is KHSRP; the disease is glioma.