High expression of BCYRN1 acts as a ceRNA, sponging miR-619-5p to regulate the expression of CUE domain-containing protein 2 (CUEDC2) and the PTEN/AKT/p21 pathway, ultimately inhibiting cell proliferation and migration of glioma cell lines, which offers new insights for glioma treatment. Here, CUEDC2 is linked to central nervous system cancer.