Li et al. [104] found that lncRNA HOTAIRM1 mediates the demethylation of histone H3K9 and H3K27, reducing DNA methylation levels by sequestering epigenetic modifiers G9a and EZH2, and potentially affecting GBM cell proliferation, migration, invasion, and apoptosis suppression, providing a new approach for targeting HOTAIRM1 in GBM treatment. This evidence concerns the gene EHMT2 and glioblastoma.