For example, using microarray technology to detect the expression of LncRNA-MUF in GBM, it was found that the expression of LncRNA-MUF was significantly upregulated, and it was confirmed that the high expression of lncRNA MUF enhanced the phosphorylation of SMAD2/3 downstream of the TGF-β pathway and the gene expression of TGF-b target gene subgroups in cis and trans, thereby enhancing the resistance of GBM to temozolomide (TMZ) [87]. This evidence concerns the gene SMAD2 and glioblastoma.