Therefore, to further explore whether CDK1 can mediate the effect of PANoptosis on the cisplatin resistance of LC by regulating ZBP1, we found that the expression of ZBP1 is downregulated after overexpression of CDK1 in LC cisplatin-resistant cells, and the overexpression of ZBP1 can rescue the influence of overexpression of CDK1 on key proteins of PANoptosis. This evidence concerns the gene CDK1 and laryngotracheoesophageal cleft.