To further investigate whether CDK1 can mediate the influence of PANoptosis on cisplatin resistance in laryngeal cancer by regulating ZBP1, pcDNA 3.1, pcDNA-CDK1 and pcDNA 3.1 or pcDNA-pcDNA-ZBP1 were transfected or cotransfected into Hep-2/R cells. This evidence concerns the gene ZBP1 and laryngeal carcinoma.