In a logistic regression model, we expressed the relationship between individual macronutrients and TIR, TAR, TBR and GCV (crude model), and subsequently adjusted for possible confounders as follows: age, sex, diabetes duration, socioeconomic status, BMI, alcohol use, sports (h/week), use of insulin pump (model 1); model 1 + other macronutrients (model 2); and model 2 + total insulin use per day (model 3). This evidence concerns the gene INS and diabetes mellitus.